May 22, 2020 · N 6-methyladenosine (m 6 A), first described in 1974 [1, 2], is a well-known internal modification of messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs); it is widely conserved among eukaryotes ranging from yeast, plants, and flies to mammals and even occurs in viral RNAs with a nuclear phase [3, 4].As the most abundant and important mRNA modification in mammals, m 6 A modification …